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KMID : 0613820140240091030
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Journal of Life Science
2014 Volume.24 No. 9 p.1030 ~ p.1038
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Plateletpheresis: the Process, Devices, and Indicators of Product Quality
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Kim Sung-In
Chang Chul-Soo
Kim Hyun-Kyung
Kweon Chang-Oh
Kim Byung-Weon
Kim Dong-Chan
Kim Yoon-Suk
Rhee Ki-Jong
Ryu Jae-Ki
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Abstract
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Platelet products are used to treat hemorrhagic or platelet dysfunction diseases. Plateletpheresis involves collecting the platelet components of blood using an apheresis blood-collection system. Various indicators are available for evaluating the qualities of the apheresis platelets. The productivity of platelet collection is evaluated through both the collection efficiency and collection rates. Platelet storage quality can be evaluated in vitro using several indicators, including visual appearance, metabolic activities, volume, platelet count, white blood cell count, microparticles, and various platelet activation markers. Platelet activation markers have been used as indicators of storage quality in various studies. Post-transfusion platelet quality can be evaluated based on the corrected count increment and the percentage of platelet recovery. Although various studies have investigated the aspects of plateletpheresis, no article has systemically presented assessments of the platelet products obtained from different plateletpheresis devices. The present study provides a review of plateletpheresis, including the specifics of the process, the types of devices employed, the platelet quality, the overall efficacy, and the evaluation indicator qualities. Furthermore, the differences in functionality among the different apheresis devices are discussed. Although adverse reactions to the citrate anti-coagulant have been reported, apheresis processing may provide a safer option for donors who are at a high risk for presyncopal or syncopal reactions related to whole blood collection.
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KEYWORD
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Plateletpheresis, plateletpheresis devices, platelet quality indicators, platelet activation markers, platelet additive solution
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